Cytokine Storm, is one of the dangers of Swine Flu.
We think of external microbes as our worst enemy during an outbreak of influenza or bronchitis but our own immune system is potentially more lethal. When our body detects foreign microorganisms indicating an infection, our body might respond by over-protecting the site of infection. The body may race so many antibodies to the infection site that they collect in a cytokinestorm. When the infection is in the lungs, for example, a cytokinestorm can potentially block airways and result in suffocation. Medical researchers have identified the causes and stages of the cytokinestorm and are working on treatments to weaken an overactive immune response.
At all times, white blood cells circulate in the bloodstream and are the first to sense if a virus or bacteria has infiltrated the body. Immediately, our body sends immune cells, including T-cells and macrophages, to attack the infection. During this stage, our immunity functions properly, and immune cells attack the microbes so they do not get too strong a foothold in our lungs.
For reasons not completely known, too many immune cells can be sent to the infection site. This happens when a particular type of molecule in the body, known as cytokines, activate the immune cells at the infection site and cause more immune cells to flood the site of infection. This propagates what is referred to as a cytokinestorm where far too many immune cells are caught in an endless loop of calling more and more immune cells to fight the infection. The cytokinestorm ends up inflaming the tissue surrounding the infection.
When the infection is in the lungs, severe inflammation caused by a cytokinestorm can cause permanent lung damage. A prolonged cytokinestorm will eventually shut down breathing altogether. Airducts get clogged and cells no longer properly absorb oxygen. This is what makes the cytokinestorm so deadly in certain epidemic strains, such as bird flu. Even bronchitis, other varieties of influenza, pneumonia, sepsis and possibly rheumatoidarthritis are susceptible to triggering a cytokinestorm.
